Publication Abstract Display
Type: Poster
Title: Novel CSF biomarker associations with HIV-associated neurocognitive disorder (HAND).
Authors: Kallianpur A, Gittleman H, Letendre S, Ellis R, Barnholtz-Sloan J, Bush W, Heaton R, Samuels D, Franklin D, Clifford D, Collier A, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Grant I, Simpson D, Hulgan T, for the CHARTER Group
Date: 02-22-2016
Abstract:Conclusions Iron transport and altered angiogenesis may play an important role in HAND. Higher CSF CP & HP are associated with HAND in persons with minimal comorbidities. Consistent results in persons with undetectable plasma HIV RNA (≤50 copies/mL) suggest robust CP and HP associations with HAND. Increased CSF VEGF is associated with HAND in HIV-infected persons. Comorbidities have substantial impact on observed biomarker relationships with HAND. CP, HP, & VEGF are acute-phase proteins, but their effects are unlikely to merely reflect inflammation, as inflammatory cytokines were not associated with HAND in this sample. Limitations & Future Directions Source of biomarkers in CSF is unclear; systemic levels were not concurrently measured. Associations of HP & CP in persons with contributing comorbidities require further study. Analysis of systemic levels of these biomarkers in CHARTER participants with/without HAND are currently underway.

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