| Publication Abstract Display | | Type: Poster | | Title: Methamphetamine and genetically predicted expression of the cytoskeletal protein spectrin gene may interact to influence neurocognitive function in HIV+ adults. | | Authors: Bush WS, S Smieszek, T Hulgan, M Cherner, RJ Ellis, SL Letendre, DC Samuels,
DR Franklin, I Grant, RK Heaton, and AR Kallianpur | | Date: 12-01-2016 | | Abstract:In this preliminary analysis, the main effect of SPTB
gene expression predicted from genetic data was
statistically significant, with increased SPTB expression
associated with higher GDS (more NCI) in HIV+ adults.
SPTB encodes spectrin, a cytoskeletal protein which is
implicated in Alzheimer’s disease and has key roles in
calcium homeostasis and red cell membrane function.
Considerably more investigation is required to
determine 1) concomitant non-METH exposures (e.g.,
cannabis) that may track with lifetime METH and
confound its effects on GDS in HIV+ persons; 2) how
well this model reflects gene expression in brain tissue
(vs. blood); and 3) mechanistic pathways underlying
the METH x SPTB interaction that may inform therapy.
Lifetime METH significantly alters the relationships
between germline genetic variants that influence SPTB
expression and neurocognitive function in HIV+ adults. |
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