Publication Abstract Display | Type: Poster | Title: Impact of advancing age on cognition in HIV+ persons on a first suppressive regimen. | Authors: Coban H, Robertson K, Smurzynski M, Krishnan S, Wu K, Bosch R, Collier A, Ellis R | Date: 02-13-2017 | Abstract:Conclusions:
In the context of long-term ART (2 or more years after starting initial treatment), older age was a significant risk factor for neurocognitive impairment
Age-related neurocognitive impairment was seen despite continued virologic suppression in most and despite neurocognitive improvement (lower impairment rate at later follow-up visits) in the cohort as a whole.
Potential causes of age-related neurocognitive impairment:
ART-related adverse effects of common age-related comorbidities (diabetes, hypertension, hyperlipidemia)
Greater CNS toxicities of ART in older versus younger participants. |
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