| Publication Abstract Display | | Type: Published Abstract | | Title: Plasma (1→3)-β-d-glucan levels correlate with neurocognitive performance in HIV. | | Authors: Hoenigl M, Letendre SL, Iudicello J, Franklin D, Porrachia M, Vargas M, Ellis RJ, Finkelman M, Gianella S | | Year: 2019 | | Publication: CROI | | Volume: Issue: Pages: | | Abstract:Although antiretroviral therapy (ART) has improved survival and morbidity, people living with HIV (PLWH) have higher rates of non-AIDS disorders, such as neurocognitive (NC) impairment (NCI), than the general population. (1-3)-b-D-glucan (BDG) is a fungal cell wall component which – in the absence of fungal infections – serves as biomarker for gut barrier integrity failure and microbial translocation. The objective of this study was to determine whether higher plasma and cerebrospinal fluid (CSF) levels of BDG are associated with NCI in PLWH. |
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