Publication Abstract Display
Type: Published Abstract
Title: Neuropsychological profile and prognostic significance of minor cognitive/motor disorder.
Authors: Heaton RK, Marcotte TD, Ellis RJ, Deutsch R, Abramson I, Grant I, and the HNRC Group
Year: 1996
Publication: Journal of NeuroVirology
Volume: 2 Issue: Pages: 39
Abstract:A diagnosis of Minor Cognitive/Motor Disorder (MCMD) indicates that a patient has HIV-relates neuropsychological (NP) impairment that causes at least mild interferences with daily functioning. Of 494 HIV+ subjects who completed comprehensive NP and neurological evaluations and were diagnosed by a multidisciplinary team, 319 were identified as NP normal, 112 were NP impaired but without everyday functioning difficulties (NPI), and 63 met MCMD criteria. The highest rates of MCMD were in CDC Stages B (28%) and C (32%). Compared to the NPI category, the diagnosis of MCMD was associated with more severe NP impairment that affected more ability domains. Significantly increased impairment rates were specifically found in the perceptual-motor, learning, and motor domains. Over a median follow-up period of 2.4 years, the original MCMD and NPI groups showed increased mortality rates when compared to the NO-normals (RR-2.3 for MCMD and 1.8 for NPI, after adjustments for CD4 cell counts and disease stage). Moreover, MCMD subjects who survived were significantly more likely to show NP worsening on follow-up. We conclude that NP impairment, and particularly the syndrome of MCMD, has adverse prognostic significance.

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