Publication Abstract Display | Type: Published Abstract | Title: Neuropsychological decline and neurocognitive diagnostic stability in HIV-infected individuals. | Authors: Marcotte TD, Heaton RK, Ellis RJ, McCutchan JA, Atkinson JH, Grant I, and the HNRC Group | Year: 1998 | Publication: Journal of the International Neuropsychological Society | Volume: 4 Issue: 1 Pages: 33 | Abstract:Although the prevalence of HIV-related neuropsychological (NP) impairment
has been well documented, data regarding NP change over time has
been limited. Nine hundred seventy-two subjects underwent a baseline NP
evaluation and were assigned a neurocognitive diagnosis by a multidisciplinary
team. The diagnostic classifications consisted of NP normal, subsyndromic
NP impairment (NP impairment but no deficits in everyday
functioning), Minor cognitive motor disorder, and dementia. At each successive
year of follow-up during a 3-year period, AIDS subjects had the
highest rate of NP worsening, followed by HIV-positive non-AIDS subjects
and HIV-negative subjects, respectively. Most subjects received a similar
diagnosis after 2 years of follow-up; however, there was significant
movement between diagnostic classifications. The disease thus appears to
be characterized by a pattern of general decline with periods of remission
in cognitive symptomatology. |
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