| Publication Abstract Display | | Type: Published Manuscript | | Title: Risk for cognitive impairment among HIV-infected persons with Bipolar Disorder. | | Authors: Moore DJ, Depp CA, Posada C, Parikh M, Bhatt A, Moseley S, Vigil O, Everall IP, Atkinson JH, Grant I, and the HNRC Group | | Year: 2008 | | Publication: Dialogues in Clinical Neuroscience | | Volume: 10 Issue: 2 Pages: 256-260 | | Abstract:Clinicians and clinical neuroscientists are aware that individuals with bipolar disorder are at
greater risk for developing serious medical, psychiatric, and substance-use comorbidities as
compared with the general population. Less widely appreciated, however, is the observation
that HIV infection appears to be more prevalent among persons with bipolar disorder and that
both conditions pose significant risk for cognitive impairment. Higher rates of HIV infection
among persons with bipolar disorder should not be surprising, given that infection and transmission
of HIV involves risk factors that converge with bipolar disorder (eg, impulsivity, substance
abuse). These factors likely also worsen adherence to treatment for both bipolar and HIV
illness, and may adversely impact health-related quality of life and therapeutic outcomes. The
public health consequence may be that nonadherence to antiretroviral therapy could lead to
higher rates of transmission of treatment-resistant strains of HIV that can evolve with sporadic
adherence. The intersection of bipolar disorder and HIV therefore merits discussion by clinicians,
researchers, and policy makers. |
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