Publication Abstract Display
Type: Published Manuscript
Title: HIV-associated neurocognitive disorders: is there a hidden epidemic?
Authors: McArthur JC, Brew BJ
Year: 2010
Publication: AIDS
Volume: 24 Issue: 9 Pages: 1367-1370
Abstract:The neurocognitive disorders associated with HIV (HAND) remain among the most common clinical disorders encountered in people infected with HIV, even in an era in which potent antiretroviral therapy is widely deployed. With the improved survival of individuals treated with antiretrovirals, comorbid conditions have become increasingly salient, including particularly co-infection with hepatitis C, and the effects of aging. Various consensus groups have developed treatment guidelines for preferred initial antiretroviral regimens and for second or salvage regimens. Unfortunately, current recommendations are essentially silent on the approach to HAND. For example, HIV-nephropathy is one indication for initiation of HAART, yet inexplicably HAND is not, unless it is severe enough to manifest as dementia. As with most antimicrobials, brain penetration is crucial to achieve the goal of maximal suppression of HIV replication.

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