Publication Abstract Display
Type: Published Manuscript
Title: Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV infected individuals.
Authors: Lin K, Taylor MJ, Heaton RK, Franklin D, Jernigan TL, Fennema-Notestine C, McCutchan A, Atkinson JH, McArthur J, Morgello Simpson D, Collier A, Marra C, Gelman B, Clifford D, Grant I, and the CHARTER Group
Year: 2011
Publication: Journal of Clinical and Experimental Neuropsychology
Volume: 33 Issue: Pages: 326-334
Abstract:We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (Human immunodeficiency virus) associated neurocognitive complications. HIV infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.

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