| Publication Abstract Display | | Type: Published Manuscript | | Title: Neurocognitive deficits in HIV-infected women and victims of childhood trauma. | | Authors: Spies G, Fennema-Notestine C, Archibald SL, Cherner M, Seedat S | | Year: 2012 | | Publication: AIDS Care | | Volume: 24 Issue: 9 Pages: 1126-1135 | | Abstract:The studyinvestigated the behavioral and brain effects of childhood trauma and human immunodeficiency virus
(HIV) infection, both separatelyand in combination, and assessed potential interactions in women who were
duallyaffected. Eighty-three HIV-positive and 47 matched HIV-negative South African women underwent
neuromedical, neuropsychiatric, and neurocognitive assessments. Univariate tests of significance assessed if either
HIV infection or childhood trauma, or the combination, had a significant effect on neurocognitive performance.
The majority of women were Black (96%) and had an average age of 30 years. An analysis of covariance revealed
significant HIV effects for the Hopkins Verbal Learning Test (HVLT) learning and delaytrials (pB0.01) and the
Halstead CategoryTest (HCT) (pB0.05). A significant trauma effect was seen on the HVLT delaytrial
(pB0.05). The results provide evidence for neurocognitive dysfunction in memory and executive functions in
HIV-infected women and memorydisturbances in trauma exposed women. |
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