| Publication Abstract Display |
| Type: Published Manuscript |
| Title: HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma. |
| Authors: Reid E, Morris SR |
| Year: 2012 |
| Publication: Infectious Agents and Cancer |
| Volume: 7 Issue: 1 Pages: 6 |
| Abstract:In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04). |