| Publication Abstract Display | | Type: Published Manuscript | | Title: Prospective memory and antiretroviral medication non-adherence in HIV: An analysis of ongoing task delay length using the memory for intentions screening test. | | Authors: Poquette AJ, Moore DJ, Gouaux B, Morgan EE, Grant I, Woods SP | | Year: 2013 | | Publication: Journal of The International Neuropsychological Society : JINS | | Volume: 19 Issue: 2 Pages: 155-161 | | Abstract:Using multi-process framework by McDaniel and Einstein (2000), the current study examined whether the length of prospective memory (PM) delay intervals as measured by the 2- and 15-min subscales of the Memory for Intentions Screening Test (MIST) have differential predictive value for antiretroviral (ARV) adherence. Participants included 74 HIV-infected individuals whose ARV adherence was tracked with an electronic monitoring system. Participants were classified as adherent (n = 49) or non-adherent (n = 25) based on recorded pill bottle openings of ≥90% of prescribed doses over 30 days. An adherence group by MIST delay interval interaction was observed, such that non-adherent participants had worse performance on the 15-min, but not 2-min delay PM MIST subscales. The observed MIST 15-min delay effects were significantly more pronounced on time- versus event-cued PM trials. Long-delay time-based PM was predictive of non-adherence independent of demographics, mood state, self-reported adherence, and general cognitive functioning. Findings from this clinical study indicate that ARV non-adherence may be particularly associated with deficits in strategic cue monitoring over longer PM delays, which may inform interventions to improve adherence among persons living with HIV infection. |
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