Publication Abstract Display
Type: Published Manuscript
Title: Characterizing HIV medication adherence for virologic successes among individuals living with HIV/AIDS: Lessons from the CNS HIV Antiretroviral Therapy Effects Research.
Authors: Biswas B, Spitznagel E, Collier A, Gelman B, McArthur J, Morgello S, McCutchan JA, Clifford DB and the CHARTER Group
Year: 2014
Publication: Journal of HIV/AIDS & Social Services
Volume: 13 Issue: 1 Pages: 8-25
Abstract:Antiretroviral therapy (ART) has changed infection with HIV from a terminal illness to a chronic disease by suppressing viral load to undetectable levels. Success with ART is dependent on optimal adherence to a strict regimen, widely accepted at >95%. As medication type, class and frequency of use continue to evolve, we assessed adherence levels related to viral suppression. Using a cross-sectional analysis with secondary data (n = 381) from an ongoing multi-site study on impact of ART on the Central Nervous System (CNS), we compared selfreported adherence rates with biological outcomes of HIV-RNA copies/ml, and CD4 cell/ mm3. Adherence to ART measures included taking all prescribed medication as directed on schedule and following dietary restrictions. While depression was a barrier to adherence, undetectable viral suppression was achieved at pill adherence percentages lower than 95%. Practice, research and policy implications are discussed in the context of patient-, provider-, and system-level factors influencing adherence to ART.

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