Publication Abstract Display
Type: Published Manuscript
Title: Using ultradeep pyrosequencing to study HIV-1 co-receptor usage in primary and dual infection.
Authors: Wagner GA, Pacold ME, Vigil E, Caballero G, Morris SR, Pond SLK, Little SJ, Richman DD, Gianella S, Smith DM
Year: 2013
Publication: The Journal of Infectious Diseases
Volume: 208 Issue: 2 Pages: 271-274
Abstract:HIV-1 dual infection (DI) and CXCR4 (X4) co-receptor usage are associated with accelerated disease progression but frequency and dynamics of co-receptor usage during DI is unknown. Ultradeep sequencing was used to interrogate for DI and infer co-receptor usage in longitudinal blood samples of 102 subjects. At baseline, X4 usage was high (23 subjects harbored X4 variants), and was not associated with infection duration or DI. Co-receptor usage changed over time in 12/47 participants, and X4 usage emerged in 4/41 monoinfections vs. 2/5 superinfections (p=0.12), suggesting a weak statistical trend towards occurrence of superinfection and acquiring X4 usage.

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