Publication Abstract Display
Type: Published Manuscript
Title: Novel codon insert in HIV-1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.
Authors: Chaillon A, Gianella S, Vasquez H, Ignacio C, Zweig AC, Richman DD, Smith DM
Year: 2014
Publication: AIDS Research And Human Retroviruses
Volume: 30 Issue: 2 Pages: 165-169
Abstract:We investigated the pol genotype in two phylogenetically and epidemiologically linked partners, who were both experiencing persistent low-level viremia during antiretroviral therapy. In one partner we identified a new residue insertion between codon 248 and 249 of the HIV-1 RNA reverse transcriptase (RT) coding region (HXB2 numbering). We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach.

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