| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Differences in evolution of HIV-1 Subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses. |
| Authors: Saravanan S, Gomathi S, Kausalya B, Boobalan J, Murugavel KG, Balakrishnan P, Mothi SN, Solomon SS, Kumarasamy N, Selvamuthu P, Solomon S, Smith DM |
| Year: 2015 |
| Publication: AIDS Research And Human Retroviruses |
| Volume: 31 Issue: 6 Pages: 655-7 |
| Abstract:In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region. |