Publication Abstract Display
Type: Published Manuscript
Title: Differences in evolution of HIV-1 Subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses.
Authors: Saravanan S, Gomathi S, Kausalya B, Boobalan J, Murugavel KG, Balakrishnan P, Mothi SN, Solomon SS, Kumarasamy N, Selvamuthu P, Solomon S, Smith DM
Year: 2015
Publication: AIDS Research And Human Retroviruses
Volume: 31 Issue: 6 Pages: 655-7
Abstract:In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

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