Publication Abstract Display
Type: Published Manuscript
Title: Subtype associations with HIV-associated neurocognitive disorder in China.
Authors: Day TRC, Smith DM, Heaton RK, Franklin D, Tilghman MW, Letendre S, Jin H, Wu Z, Shi C, Yu X, Perez-Santiago J
Year: 2016
Publication: Journal of Neurovirology
Volume: 22 Issue: 2 Pages: 246-250
Abstract:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4+ nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p < 0.01) and CD4+ counts (p = 0.03). HAND was also associated with AIDS (p < 0.01), but subtype was not (p = 0.198). Furthermore, worse impairment correlated with higher viral diversity (r = 0.16, p < 0.01), lower nadir (r = -0.17, p < 0.01), and CD4+ counts (r = -0.11, p = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND.

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