| Publication Abstract Display | | Type: Published Manuscript | | Title: Effect of Cytomegalovirus and HIV transcription on CD57 and PD-1 T cell expression during suppressive ART. | | Authors: Dan JM, Massanella M, Smith DM, Spina CA, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S | | Year: 2016 | | Publication: Journal of Acquired Immune Deficiency Syndromes (1999) | | Volume: 72 Issue: 2 Pages: 133-137 | | Abstract:HIV-infected men who have sex with men (MSM) are nearly universally co-infected with cytomegalovirus (CMV). In this study of 45 HIV-infected MSM virologically suppressed on ART, we found that presence of seminal CMV DNA shedding and higher levels of systemic cellular HIV RNA transcription were both independently associated with increased PD-1 expression on circulating CD4 T cells, but not with higher levels of senescent (CD57) T cells. Additionally, greater HIV RNA transcription was associated with lower CD57 expression on CD8 T cells. Although causality cannot be inferred from this retrospective study, these results suggest that asymptomatic CMV replication and residual cellular HIV transcription may contribute to persistent immune dysregulation during suppressive ART. |
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