Publication Abstract Display
Type: Published Manuscript
Title: Increased intrathecal immune activation in virally suppressed HIV-1 infected patients with neurocognitive impairment.
Authors: Edén A, Marcotte TD, Heaton RK, Nilsson S, Zetterberg H, Fuchs D, Franklin D, Price RW, Grant I, Letendre SL, Gisslén M
Year: 2016
Publication: PloS One
Volume: 11 Issue: 6 Pages: e0157160
Abstract:Although milder forms of HIV-associated neurocognitive disorder (HAND) remain prevalent, a correlation to neuronal injury has not been established in patients on antiretroviral therapy (ART). We examined the relationship between mild HAND and CSF neurofilament light protein (NFL), a biomarker of neuronal injury; and CSF neopterin, a biomarker of CNS immunoactivation, in virally suppressed patients on antiretroviral therapy (ART).

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