Publication Abstract Display | Type: Published Manuscript | Title: Etravirine and Rilpivirine drug resistance among HIV-1 Subtype C infected children failing non -nucleoside reverse transcriptase inhibitor-based regimens in South India. | Authors: Saravanan S, Kausalya B, Gomathi S, Sivamalar S, Pachamuthu B, Poongulali S, Pradeep A, Sunil SS, Mothi SN, Smith DM, Kantor R | Year: 2017 | Publication: AIDS Research And Human Retroviruses | Volume: 33 Issue: 6 Pages: 567-574 | Abstract:We have analyzed reverse transcriptase (RT) region of HIV-1 pol gene from 97 HIV-infected children who were identified as failing first-line therapy that included a first generation non-nucleoside reverse transcriptase inhibitors (Nevirapine and Efavirenz) for at least 6 months. We found that 54% and 65% of the children had genotypically predicted resistance to second generation non-nucleoside reverse transcriptase inhibitors drugs Etravirine and Rilpivirine, respectively. These cross-resistance mutations may compromise future NNRTI based regimens, especially in resource-limited settings. To complement these investigations, we also analyzed the sequences in Stanford database, Monogram weighted score and DUET weighted score algorithms for ETR susceptibility and found almost perfect agreement between the three algorithms in predicting ETR susceptibility from genotypic data. |
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