Publication Abstract Display
Type: Published Manuscript
Title: Frailty and components of the frailty phenotype are associated with modifiable risk factors and antiretroviral therapy.
Authors: Erlandson KM, Wu K, Koletar SL, Kalayjian RC, Ellis RJ, Taiwo B, Palella FJ, Tassiopoulos K
Year: 2017
Publication: The Journal of Infectious Diseases
Volume: 215 Issue: 6 Pages: 933-937
Abstract:The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV) infected adults has not been well described. HIV-infected participants aged greater than or equal 40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6 percent were frail, and 38 percent were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.

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