| Publication Abstract Display | | Type: Published Manuscript | | Title: Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy. | | Authors: Erlandson KM, Wu K, Koletar SL, Kalayjian RC, Ellis RJ, Taiwo B, Palella FJ, Tassiopoulos K | | Year: 2017 | | Publication: The Journal of Infectious Diseases | | Volume: 215 Issue: 6 Pages: 933-937 | | Abstract:The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)-infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions. |
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