| Publication Abstract Display | | Type: Published Manuscript | | Title: Molecular features of the V1-V4 coding region of sexually transmitted HIV-1. | | Authors: Choi JY, Pond SLK, Anderson CM, Richman DD, Smith DM | | Year: 2017 | | Publication: The Journal of Infectious Diseases | | Volume: 215 Issue: 10 Pages: 1506-1513 | | Abstract:Background:
Investigations into which HIV-1 sequence features may be selected for transmission during sexual exposure have been hampered by the small number of characterized transmission pairs in individual studies.
Methods:
To boost statistical power to detect differences in glycosylation, length, and electrical charge in the HIV-1 V1-V4 coding region, we re-analyzed all available 2,485 env sequences derived from 114 subjects representing 58 transmission pairs from previous studies using mixed effects linear regression and an approach to approximate the unobserved transmitted virus.
Results:
The recipient partner had shorter V1-V4 region and fewer PNGS than sequences from the source partner. And, we detected a trend towards more PNGS and lower isoelectric points in transmitted sequences with source partner and the evolutionary tendency to shorten V1-V4 sequences, reduce the number of PNGS, and lower isoelectric points in the recipient following transmission.
Conclusions:
By using all available well-characterized env sequences from transmission pairs via sexual exposure, we were able to identify several important virologic factors that may be important in the development of biomedical preventive interventions. |
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