Publication Abstract Display
Type: Published Manuscript
Title: Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients.
Authors: Ubaida-Mohien C, Lamberty B, Dickens AM, Mielke MM, Marcotte T, Sacktor N, Grant I, Letendre S, Franklin D, Cibrowski P, Tharakan R, McArthur JC, Fox H, Haughey NJ
Year: 2017
Publication: AIDS (London, England)
Volume: 31 Issue: 10 Pages: 1365-1378
Abstract:The prevalence of HIV-associated neurocognitive disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation, and cellular stress have been repeatedly associated with HAND, but the underlying systems that drive these changes have not been identified.

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