Publication Abstract Display
Type: Published Manuscript
Title: Semantic memory in HIV-associated neurocognitive disorders: An evaluation of the "Cortical" versus "Subcortical" hypothesis.
Authors: Tierney S, Woods SP, Verduzco M, Beltran J, Massman PJ, Hasbun R
Year: 2018
Publication: Archives of Clinical Neuropsychology : The Official Journal of The National Academy of Neuropsychologists
Volume: 33 Issue: 4 Pages: 406-416
Abstract:Objective: HIV-associated neurocognitive disorders (HAND) have historically been characterized as a subcortical condition that does not affect semantic memory; however, recent evidence suggests that the cortical regions that support semantic memory may be affected in HIV. Method: The current study examined the effects of HAND on semantic memory in 85 HIV+ individuals with HAND, 193 HIV+ individuals without HAND, and 181 HIV- individuals who completed the Boston Naming Test (BNT) and the Famous Faces subtest of the Kauffman Adolescent and Adult Intelligence Test (KAIT-FF). Results: Linear regressions revealed a significant adverse effect of HAND on total scores on the BNT and the KAIT-FF (all ps < .01). Analyses of BNT errors showed that individuals with HAND committed more semantically related errors as compared to the other two study groups (all ps < .05). However, there were no group differences in rates of visually based errors, which are more commonly observed in traditional subcortical diseases (all ps > .10). Conclusions: Results indicate that HAND may impose adverse effects on individuals' object naming and identification abilities suggestive of mild semantic deficits that parallel traditional cortical diseases such as Alzheimer's disease.

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