Publication Abstract Display
Type: Published Manuscript
Title: Physical activity is associated with lower odds of cognitive impairment in women but not men living with HIV infection.
Authors: Chow FC, Makanjuola A, Wu K, Berzins B, Kim KA, Ogunniyi A, Ellis R, Robertson K, Tassiopolous K, Taiwo B
Year: 2019
Publication: The Journal of Infectious Diseases
Volume: 219 Issue: 2 Pages: 264-275
Abstract:Background: Cardiovascular comorbidities are risk factors for HIV-associated cognitive impairment. Given differences in cardiometabolic risk profiles between women and men with HIV, we investigated whether associations between cardiometabolic risk factors and prevalent cognitive impairment differ by sex. Methods: Separate logistic regression models were constructed for women and men at entry into a prospective study of older persons with HIV (PWH) to assess the association of cardiometabolic and other risk factors with cognitive impairment. Results: Of 988 participants, 20% were women. Women had higher total cholesterol (194 versus 186 mg/dL, p=0.027), hemoglobin A1c (5.9% versus 5.7%, p=0.003), and body mass index (30.8 versus 27.4 kg/m 2, p<0.001) compared with men, and were less physically active (43% versus 55%, p=0.005). In a multivariable model, physical activity was associated with lower odds of cognitive impairment in women (OR 0.35, 95% CI 0.15 to 0.80, p=0.013) but not men. Conclusion: Physical activity may have a greater positive impact on cognitive health in women than in men with HIV. This finding should be confirmed in studies examining the longitudinal association between physical activity and incident cognitive impairment in PWH and the effect of interventions that increase physical activity on cognitive impairment in women with HIV.

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