| Publication Abstract Display | | Type: Published Manuscript | | Title: Behavioral and physical activity interventions for HAND. | | Authors: Montoya JL, Henry B, Moore DJ | | Year: 2021 | | Publication: Current Topics in Behavioral Neurosciences | | Volume: 50 Issue: Pages: 479-501 | | Abstract:Approximately 30-50% of persons living with HIV manifest some degree of neurocognitive impairment. Even mild-to-moderate forms of HIV-associated neurocognitive disorders (HAND) can result in difficulties with everyday functioning, such as suboptimal medication adherence and impaired driving. Despite the pervasive presence and consequences of HAND, there is a significant unmet need to develop effective behavioral strategies to reduce the incidence and consequences of HAND. Although there is an absence of evidence-based behavioral interventions specific to HAND, the literature reviewed in this chapter suggest the following modifiable lifestyle factors as intervention targets: physical activity, diet, sleep, and antiretroviral medication adherence. Adoption and maintenance of these healthy lifestyle factors may reduce inflammation and oxidative stress, which, in turn, may reduce the incidence and/or severity of HAND. |
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