Publication Abstract Display
Type: Published Manuscript
Title: Low-level HIV RNA in cerebrospinal fluid and neurocognitive performance: A longitudinal cohort study.
Authors: Anderson AM, Tang B, Vaida F, Mcclernon D, Deutsch R, Cherner Mariana, Cookson D, Crescini M, Grant I, Ellis RJ, Letendre SL
Year: 2021
Publication: Journal of Acquired Immune Deficiency Syndromes
Volume: 87 Issue: 5 Pages: 1196-1204
Abstract:Cognitive complications persist in persons with HIV (PWH) during suppressive antiretroviral therapy (ART). Low levels of HIV during ART could contribute to these complications. In this study, we measured cerebrospinal fluid (CSF) HIV using a single copy assay (SCA) to investigate a possible relationship between low level HIV and cognition.Design/Methods: SCA data were analyzed from three consecutive paired CSF-plasma specimens collected over a mean of 456 days from 96 participants on suppressive ART. Using mixed models, the presence of CSF HIV by SCA as a risk factor for worse neurocognitive performance was examined.

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