Publication Abstract Display
Type: Published Manuscript
Title: Prevention of HIV-1 TAT protein-inducedperipheral neuropathy and mitochondrial disruption by the antimuscarinic pirenzepine.
Authors: Han MM, Frizzi KE, Ellis RJ, Calcutt NA, Fields JA
Year: 2021
Publication: Frontiers in Neurology
Volume: 12 Issue: 663373 Pages:
Abstract:HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment. HIV trans-activator of transcription (TAT) is associated with mitochondrial dysfunction and neurotoxicity in the brain and may play a role in the pathogenesis of HIV-DSP. In the present study, we measured indices of peripheral neuropathy in the doxycycline (DOX)-inducible HIV-TAT (iTAT) transgenic mouse and investigated the therapeutic efficacy of a selective muscarinic subtype-1 receptor (M

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