Publication Abstract Display
Type: Published Manuscript
Title: Neopterin relates to lifetime depression in older adults with HIV on suppressive antiretroviral therapy.
Authors: Saloner R, Savini N, Letendre SL, Moore DJ, Montoya JL
Year: 2022
Publication: Journal of Acquired Immune Deficiency Syndromes
Volume: 89 Issue: 4 Pages: 454-461
Abstract:Chronic inflammation contributes to the pathogenesis of depression in persons with HIV (PWH). Neopterin, a biomarker of HIV-related immune activation that partially normalizes with antiretroviral therapy (ART), correlates with major depressive disorder (MDD) and subclinical depressive symptoms in persons without HIV and acutely infected, young PWH. The sensitivity of neopterin, however, to both lifetime and current depression is poorly understood in older PWH on suppressive ART.

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