Publication Abstract Display
Type: Published Manuscript
Title: The evolution of assessing central nervous system complications in Human Immunodeficiency Virus: Where do we go from here?
Authors: McIntosh RC, Clark US, Cherner M Cysique LA, Heaton RK, Levin J, Remien RH, Thames A, Moore DJ, Rubin LH
Year: 2023
Publication: The Journal of Infectious Diseases
Volume: 227 Issue: Supplement_1 Pages: S30-S37
Abstract:In this fifth decade of the human immunodeficiency virus (HIV) epidemic, central nervous system (CNS) complications including cognitive impairment and mental health remain a burden for people with HIV (PWH) on antiretroviral therapy. Despite the persistence of these complications, which often co-occur, the underlying pathophysiology remains elusive and consequently treatments remain limited. To continue to grow our understanding of the underlying mechanisms of CNS complications among PWH, there is a need to reexamine our current approaches, which are now more than 2 decades old. At the 2021 National Institutes of Health-sponsored meeting on Biotypes of CNS Complications in PWH, the Neurobehavioral Working Group addressed the following: (1) challenges inherent to determining CNS complications; (2) heterogeneity in CNS complications; and (3) problems and solutions for examining integrated biotypes. The review below provides a summary of the main points presented and discussed by the Neurobehavioral Working Group at the meeting.

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