| Publication Abstract Display | | Type: Published Manuscript | | Title: Evaluation of archival HIV DNA in brain and lymphoid tissues. | | Authors: Oliveira MF, Pankow A, Vollbrecht T, Kumar NM, Cabalero G, Ignacio C, Zhao M Vitomirov A, Gouaux B, Nakawawa M, Murrell B, Ellis RJ, Gianella S | | Year: 2023 | | Publication: Journal of Virology | | Volume: 97 Issue: 6 Pages: e0054323 | | Abstract:HIV reservoirs persist in anatomic compartments despite antiretroviral therapy (ART). Characterizing archival HIV DNA in the central nervous system (CNS) and other tissues is crucial to inform cure strategies. We evaluated paired autopsy brain-frontal cortex (FC), occipital cortex (OCC), and basal ganglia (BG)-and peripheral lymphoid tissues from 63 people with HIV. Participants passed away while virally suppressed on ART at the last visit and without evidence of CNS opportunistic disease. We quantified total HIV DNA in all participants and obtained full-length HIV-envelope (FL HIV- |
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