Publication Abstract Display
Type: Published Manuscript
Title: Reply to Augello, PA; Wu, J. Comment on "Rogers et al. The combined effects of cannabis, methamphetamine, and HIV on neurocognition".
Authors: Rogers JM, Iudicello JE, Marcondes MCG, Morgan EE, Cherner M, Ellis RJ, Letendre SL, Heaton RK, Grant I
Year: 2023
Publication: Viruses
Volume: 15 Issue: 9 Pages:
Abstract:We thank Augello and Wu [ 1] for their interest in our manuscript and for bringing to our attention these inconsistencies between the modeled slopes and the group means presented in the figures. We regret that this did not come to our attention sooner, and we have gone about trying to determine the source of these discrepancies. Your point that there should be concordance between the group mean differences (whether as modeled T-scores or probabilities of impairment) derived from the figures and the model slope estimates presented in the tables is well taken. These should be parallel to one another. After re- examining the analysis syntax and implementing another contrast coding strategy with the same comparisons (backward deviance coding), but which are specified in different directions (see below), estimates matched the fitted values displayed in the profile plots. The corrected results are largely consistent with the main conclusions originally reported in the manuscript; namely, that M+C+ displayed better neurocognitive performance and lower rates of impairment than M+C−. The corrected results are different from those reported in the manuscript in terms of the effect size reported. Additionally, the corrected results now support the notion that M+C+ did not display a worse performance than a comparison group without these substance use disorder histories (M−C−). People with only cannabis use disorder histories (M−C+) still displayed better overall performance than M−C−, but they did so in different subdomains than originally reported. All corrections discussed have been addressed in a Correction submitted by the authors.

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