| Publication Abstract Display | | Type: Published Manuscript | | Title: Reply to Augello, PA; Wu, J. Comment on "Rogers et al. The combined effects of cannabis, methamphetamine, and HIV on neurocognition". | | Authors: Rogers JM, Iudicello JE, Marcondes MCG, Morgan EE, Cherner M, Ellis RJ, Letendre SL, Heaton RK, Grant I | | Year: 2023 | | Publication: Viruses | | Volume: 15 Issue: 9 Pages: | | Abstract:We thank Augello and Wu [ 1] for their interest in our manuscript and for bringing
to our attention these inconsistencies between the modeled slopes and the group means
presented in the figures. We regret that this did not come to our attention sooner, and we
have gone about trying to determine the source of these discrepancies. Your point that there
should be concordance between the group mean differences (whether as modeled T-scores
or probabilities of impairment) derived from the figures and the model slope estimates
presented in the tables is well taken. These should be parallel to one another. After re-
examining the analysis syntax and implementing another contrast coding strategy with
the same comparisons (backward deviance coding), but which are specified in different
directions (see below), estimates matched the fitted values displayed in the profile plots.
The corrected results are largely consistent with the main conclusions originally reported
in the manuscript; namely, that M+C+ displayed better neurocognitive performance and
lower rates of impairment than M+C−. The corrected results are different from those
reported in the manuscript in terms of the effect size reported. Additionally, the corrected
results now support the notion that M+C+ did not display a worse performance than a
comparison group without these substance use disorder histories (M−C−). People with
only cannabis use disorder histories (M−C+) still displayed better overall performance than
M−C−, but they did so in different subdomains than originally reported. All corrections
discussed have been addressed in a Correction submitted by the authors. |
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