| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Symptomatic HIV seroconverting illness is associated with more rapid neurologic impairment. |
| Authors: Wallace MR, Nelson JA, McCutchan JA, Wolfson T, Grant I, and the HNRC Group |
| Year: 2001 |
| Publication: Sexually Transmitted Infections |
| Volume: 77 Issue: Pages: 199-201 |
| Abstract:Objectives: To establish whether symptomatic seroconverting illness in HIV infected people is associated with more rapid development of neurological impairment.
Methods: 166 HIV infected subjects with a known date of HIV infection enrolled in a longitudinal study of neurocognitive function were stratified by whether or not they had experienced a symptomatic serconverting illness.
Results: 29 of 166 (17.5%) dated HIV seroconverters had a history of symptomatic seroconverting illness. Though baseline neurocognitive function was similar, subjects with a symptomatic seroconverting illness developed clinical neurocognitive impairment significantly more rapidly than their asymptomatic counterparts in a survival analysis model (636 v 1075 days till impaired).
Conclusion: Symptomatic seroconverting illness predisposes to more rapid neurocognitive impairment. |