Publication Abstract Display
Type: Published Manuscript
Title: Abnormalities of the brain in AIDS patients: correlation of postmortem MR findings with neuropathology.
Authors: Grafe MR, Press GA, Berthoty DP, Hesselink JR, Wiley CA
Contact: Department of Pathology, University of California, School of Medicine, San Diego 92103.
Year: 1990
Publication: AJNR. American Journal of Neuroradiology
Volume: 11 Issue: 5 Pages: 905-11; discussion 912
Abstract:The ability of MR to detect CNS lesions in AIDS patients was evaluated by postmortem scanning of 10 formalin-fixed brains. Nine patients had premortem mental status changes and five had focal neurologic deficits. The brains were imaged and sectioned in corresponding planes. MR images showed atrophy in eight of the 10. All grossly identified lesions and areas of MR abnormality were histologically evaluated. Areas of infarction and necrosis associated with cytomegalovirus (CMV) or Toxoplasma gondii were seen as foci of increased signal intensity. Severe ventriculitis and focal gliosis were also visible by MR. Neither CT nor MR was able to detect diffuse CMV- or HIV-associated microglial nodules. Dementia without focal neurologic signs correlated best with the presence of diffuse microglial nodules at pathology. Our results demonstrate the usefulness of correlating postmortem MR imaging with neuropathology, and the relevance of postmortem findings to the interpretation of MR images in living patients.
Funding: NINDS:NS NS 25178, NINDS:NS NS-00928
Keywords: Acquired Immunodeficiency Syndrome, Adult, Atrophy, Brain, Brain Diseases, False Negative Reactions, False Positive Reactions, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Tomography, X-Ray Computed

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