Publication Abstract Display
Type: Published Manuscript
Title: Indinavir population pharmacokinetics in plasma and cerebrospinal fluid.
Authors: Letendre SL, Capparelli EV, Ellis RJ, McCutchan JA, and the HNRC Group
Contact: HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA.
Year: 2000
Publication: Antimicrobial Agents and Chemotherapy
Volume: 44 Issue: 8 Pages: 2173-5
Abstract:Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curves was 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range.
Funding: NIDA:DA 1 PO1 DA12065-01A1, NIAID:AI AI 07384, NIMH:MH R01-MH-58076-04
Keywords: Chromatography, High Pressure Liquid, HIV Infections, HIV Protease Inhibitors, Humans, Indinavir, Male, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.

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