| Publication Abstract Display | | Type: Published Manuscript | | Title: Immune predispositions for cytomegalovirus retinitis in AIDS. | | Authors: Schrier RD, Freeman WR, Wiley CA, McCutchan JA, and the HNRC Group | | Contact: Department of Pathology, University of California, San Diego, La Jolla 92093, USA. | | Year: 1995 | | Publication: The Journal of Clinical Investigation | | Volume: 95 Issue: 4 Pages: 1741-6 | | Abstract:CMV retinitis develops in approximately 28-35% of all AIDS patients at later stages of disease, often leading to blindness. To determine whether the subset of AIDS patients who developed CMV retinitis (CMV-R) were immunologically predisposed, T cell proliferation responses to CMV were examined prospectively in an HIV infected, HLA typed, longitudinal study population. Individuals who developed CMV-R had significantly lower T cell proliferation responses to CMV, both early and late in disease, compared to CD4matched controls who have not developed CMV-R. Since HLA proteins influence T-cell recognition, phenotypes of 21 CMV-R patients were examined to determine whether certain HLA alleles were associated with low immune response and predisposed AIDS patients to CMV-R. HLA DR7 and B44 were at increased (nearly twice the expected) frequency in those with CMV-R. The combined association of either B44, 51 or DR7 with CMV-R was highly significant (P = .008, relative risk of CMV-R = 15) with correction for multiple comparisons. Low immune responses were twice as frequent in those with (61%) compared to those without (30%) predisposing alleles. Thus, AIDS patients with immunogenetically related hyporesponsiveness to CMV antigens may be at increased risk of retinitis. | | Funding: NEI:EY R01-EY07366, NIMH:MH R01-MH46790, CSAP:SP SP50 MH 45294 | | Keywords: Acquired Immunodeficiency Syndrome, Cytomegalovirus Retinitis, Female, Gene Frequency, HLA Antigens, HLA-B Antigens, HLA-DR7 Antigen, Humans, Immune Tolerance, Longitudinal Studies, Lymphocyte Activation, Male, Prospective Studies, Research Support, U.S. Gov't, P.H.S., Risk Factors, T-Lymphocytes |
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