Publication Abstract Display
Type: Published Manuscript
Title: Testing HIV molecular biology in in silico physiologies.
Authors: Sieburg HB, Baray C, Kunzelman KS
Contact: Department of Psychiatry, University of California, San Diego 92093-0603, USA.
Year: 1993
Publication: Proceedings / International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology
Volume: 1 Issue: Pages: 354-61
Abstract:The natural and medical sciences have strongly benefitted from technological advances that help to create and store more raw information than can be effectively processed. In particular, this rapid growth has created a strong need for a flexible and far-reaching approach to cross-database simulation. The paper uses a highly simplified example, called the 'TinyMouse' simulator, to explain the design and functioning of interactive cross-database simulators that can be applied to prototype experiments with animal models of human disease, such as the hu-SCID mouse model for the Acquired Immune Deficiency Syndrome (AIDS). Work in progress is discussed to extend 'TinyMouse' into 'CyberMouse', an informational organism that synthesizes factual databases of the murine neuroendocrine-immune system.
Funding: NIMH:MH MH 45688
Keywords: Animals, Computer Communication Networks, Computer Simulation, HIV, HIV Infections, Humans, Immune System, Mice, Mice, SCID, Models, Biological, Models, Genetic, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Software Design

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