Publication Abstract Display
Type: Published Manuscript
Title: Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex.
Authors: Espey MG, Ellis RJ, Heaton RK, Basile AS
Year: 1999
Publication: Neurology
Volume: 53 Issue: 5 Pages: 1144-5
Abstract:Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-1-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 micromol/L) and either HIV-1 infection or HIV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.

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