Publication Abstract Display
Type: Published Manuscript
Title: Expression of stromal cell-derived factor 1 alpha protein in HIV encephalitis.
Authors: Langford D, Sanders VJ, Mallory M, Kaul M, Masliah E
Contact: Department of Pathology, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.
Year: 2002
Publication: Journal of Neuroimmunology
Volume: 127 Issue: 1-2 Pages: 115-26
Abstract:Analysis of the patterns of stromal cell-derived factor 1alpha (SDF-1alpha) expression in the brains from HIV-positive patients suggests that in neuronal cells, SDF-1alpha might play a role in neuroprotection and neurite extension in response to HIV infection. In all cases analyzed, SDF-1alpha immunoreactivity was primarily present in astroglial cells. Patients with HIV encephalitis (HIVE) showed intense somato-dendritic neuronal SDF-1alpha immunoreactivity, while HIVE negative patients with neurodegeneration had asignificant decrease in neuronal SDF-1alpha immunoreactivity. Neuronal cells treated with SDF-1alpha displayed increased neurite outgrowth. Similarly, neurons treated with HIV-Tat, which induced SDF-1alpha expression, also showed neurite outgrowth. Tat-mediated neurite outgrowth was blocked by anti-SDF-1alpha antibody. These results suggest that SDF-1alpha may play a role in the neuronal response to HIV in the brains of AIDS patients.
Funding: NIDA:DA DA 12065, NIMH:MH MH 12549-01, NIMH:MH MH 45294, NIMH:MH MH 59745
Keywords: AIDS Dementia Complex, Adult, Antibodies, Brain, Cell Line, Chemokines, CXC, Gene Products, tat, Humans, Immunohistochemistry, Middle Aged, Neurites, Neuroglia, Neurons, Research Support, U.S. Gov't, P.H.S.

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