| Publication Abstract Display | | Type: Published Manuscript | | Title: Proteomic pointers in HIV neurocognitive disorder. | | Authors: Everall I, Grant I | | Contact: Section of Experimental Neuropathology and Psychiatry, Institute of Psychiatry, King's College, London SE5 8AF, UK. i.everall@iop.kcl.ac.uk | | Year: 2004 | | Publication: Lancet | | Volume: 363 Issue: 9415 Pages: 1091-2 | | Abstract:Recently, Xiaoguang Luo and colleagues1 identified a macrophage protein fingerprint by proteomic profiling that distinguishes individuals with HIV-1-related cognitive impairments from those who are unimpaired. This observation, on a general level, shows the potential power of proteomics (the analysis of the protein complement of the genome) for the analysis of cellular proteins and how they may vary in disease. The study also raises intriguing possibilities about the causation and identification of HIV-related cognitive impairments. | | Keywords: AIDS Dementia Complex, Adult, Cognition Disorders, Electrophoresis, Gel, Two-Dimensional, Female, Follow-Up Studies, HIV-1, Humans, Macrophages, Middle Aged, Monocytes, Peptide Mapping, Protein Array Analysis, Proteome, Sensitivity and Specificity, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Spectrum Analysis, Mass |
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