Publication Abstract Display
Type: Published Manuscript
Title: CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults.
Authors: Singh KK, Ellis RJ, Marquie-Beck J, Letendre S, Heaton RK, Grant I, Spector SA
Contact: Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0672, USA.
Year: 2004
Publication: Journal of Neuroimmunology
Volume: 157 Issue: 1-2 Pages: 185-92
Abstract:CCR2 is a minor coreceptor for human immune deficiency virus-1 (HIV-1) and its impact on HIV-1-related neuropsychological impairment (NPI) remains unknown. We studied the impact of CCR2-V64I polymorphisms on the development of NPI in 121 HIV-1 patients. The CCR2-64-I allele was associated with rate of progression to NPI when measured from the first study visit (Log Rank p=0.01) or from the estimated time of seroconversion (p=0.02). CCR2-V64I was not associated with plasma or CSF HIV-1 RNA load, suggesting that the impact of CCR2 on neuropathogenesis may involve alterations in inflammatory responses within the CNS rather than a direct impact on viral entry or replication.
Funding: NIAID:AI AI-36214, NIAID:AI AI-39004, NIMH:MH MH 58076, NIMH:MH MH 62512
Keywords: Adult, Analysis of Variance, Cognition Disorders, Comparative Study, Female, HIV, HIV Infections, Humans, Male, Middle Aged, Monocyte Chemoattractant Protein-1, Neuropsychological Tests, Polymorphism, Genetic, Receptors, CCR5, Receptors, Chemokine, Research Support, U.S. Gov''t, P.H.S.

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