Publication Abstract Display
Type: Published Manuscript
Title: The monocyte chemotactic protein-1-2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.
Authors: Letendre S, Marquie-Beck J, Singh KK, de Almeida S, Zimmerman J, Spector SA, Grant I, Ellis R, and the HNRC Group
Contact: Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA.
Year: 2004
Publication: Journal of Neuroimmunology
Volume: 157 Issue: 1-2 Pages: 193-6
Abstract:Because monocyte chemotactic protein (MCP)-1 is an important cofactor in HIV neuropathogenesis, we investigated the relationship between MCP-1 genotype and expression in cerebrospinal fluid (CSF). We evaluated a genetic polymorphism in the MCP-1 promoter at position -2578 (alternatively designated -2518) in 98 HIV-infected subjects who had contemporaneously collected plasma and CSF. CSF MCP-1 levels were highest in the G/G genotype group, intermediate in the G/A group, and lowest in the A/A group. MCP-1 levels in plasma only differed by genotype after adjusting for HIV-related factors. Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS).
Funding: NIAID:AI AI32614, NIAID:AI AI39004, NIMH:MH K23 MH01779, NIMH:MH P30 MH652512, NIMH:MH R01 MH58076
Keywords: Adult, Alleles, Comparative Study, Demography, Female, HIV Infections, Humans, Male, Monocyte Chemoattractant Protein-1, Monocytes, Polymorphism, Single Nucleotide, RNA, Messenger, Research Support, Non-U.S. Gov''t, Research Support, U.S. Gov''t, P.H.S., Reverse Transcriptase Polymerase Chain Reaction

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