Publication Abstract Display
Type: Published Manuscript
Title: Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease.
Authors: Sadek JR, Johnson SA, White DA, Salmon DP, Taylor KI, Delapena JH, Paulsen JS, Heaton RK, Grant I
Contact: Department of Psychiatry, University of California, San Diego, CA 92103, USA.
Year: 2004
Publication: Neuropsychology
Volume: 18 Issue: 4 Pages: 692-9
Abstract:Remote memory was assessed in persons with HIV-associated dementia (HIV-D), probable Alzheimer's disease (AD), and Huntington's disease (HD) and in healthy controls. The clinical groups were similar in overall dementia severity. Each clinical group exhibited impairments on remote memory tests relative to controls; however, temporally graded memory loss with selective preservation of older information was observed in the AD group but not the HD or HIV-D group. Analysis of cued retrieval indicated a preferential cuing benefit for the HIV-D and HD groups relative to the AD group. The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D. The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage.
Funding: NIMH:MH 5P30MH62512-02, NIA:AG AG05131
Keywords: AIDS Dementia Complex, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Retrograde, Comparative Study, Dementia, Demography, Female, HIV-1, Humans, Huntington Disease, Male, Memory, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Research Support, U.S. Gov''t, P.H.S., Retrospective Studies

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