| Publication Abstract Display | | Type: Published Manuscript | | Title: Population pharmacokinetics of Abacavir in plasma and cerebrospinal fluid. | | Authors: Capparelli EV, Letendre SL, Ellis RJ, Patel P, Holland D, McCutchan JA | | Contact: Pediatric Pharmacology Research Unit (PPRU), University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103-8214, USA. ecapparelli@ucsd.edu | | Year: 2005 | | Publication: Antimicrobial Agents and Chemotherapy | | Volume: 49 Issue: 6 Pages: 2504-6 | | Abstract:The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication. | | Funding: NIMH:MH K23-MH-01779, NIMH:MH P30-MH-62512, NIMH:MH R01-MH-58076 | | Keywords: Adult, Anti-HIV Agents, Dideoxynucleosides, Drug Therapy, Combination, HIV Infections, HIV-1, Humans, Male, Models, Biological, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S., Reverse Transcriptase Inhibitors, Software |
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