Publication Abstract Display
Type: Published Manuscript
Title: Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users.
Authors: Chana G, Everall IP, Crews L, Langford D, Adame A, Grant I, Cherner M, Lazzaretto D, Heaton R, Ellis R, Masliah E, and the HNRC Group
Contact: Department of Neurosciences, University of California San Diego, La Jolla, CA 92093-0624, USA.
Year: 2006
Publication: Neurology
Volume: 67 Issue: 8 Pages: 1486-9
Abstract:The cellular basis for cognitive deficits in HIV+ patients with and without a history of methamphetamine (METH) use is unclear. We found that HIV+ METH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users.
Funding: NIDA:DA DA12065, NIMH:MH MH 62512, NIMH:MH MH45294, NIMH:MH MH58164, NIMH:MH MH59745
Keywords: Amphetamine-Related Disorders, Cadaver, Cognition Disorders, Frontal Lobe, HIV Seropositivity, Humans, Interneurons, Memory Disorders, Methamphetamine, Nerve Degeneration, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov''t, Severity of Illness Index

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