Publication Abstract Display
Type: Published Manuscript
Title: Valproic Acid does not affect markers of Human Immunodeficiency Virus disease progression.
Authors: Ances BM, Letendre S, Buzzell M, Marquie-Beck J, Lazaretto D, Marcotte TD, Grant I, Ellis RJ, and the HNRC Group
Contact: Department of Neurosciences, University of California, San Diego, California, USA.
Year: 2006
Publication: Journal of NeuroVirology
Volume: 12 Issue: 5 Pages: 403-6
Abstract:Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention.
Funding: NIMH:MH MH 62512

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