Publication Abstract Display
Type: Published Manuscript
Title: Diminished Somatostatin gene expression in individuals with HIV and Major Depressive Disorder.
Authors: Everall IP, Salaria S, Atkinson JH, Young C, Corbeil J, Grant I, Masliah E, and the HNRC Group
Contact: Department of Psychiatry, University of California, San Diego, CA 92093-0603, USA.
Year: 2006
Publication: Neurology
Volume: 67 Issue: 10 Pages: 1867-9
Abstract:In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV.
Funding: NIMH:MH MH 62512

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