Publication Abstract Display
Type: Published Manuscript
Title: Dynamics of Monocyte Chemoattractant Protein Type One (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma.
Authors: de Almeida MS, Letendre S, Zimmerman J, Lazzaretto D, McCutchan A, Ellis R
Year: 2005
Publication: Journal of Neuroimmunology
Volume: 169 Issue: 1-2 Pages: 144-52
Abstract:BACKGROUND: Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS. METHODS: MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and cerebrospinal fluid (CSF) in subjects either interrupting (TI) or starting (TS) antiretroviral therapy. RESULTS: Following TI, plasma VL rebounded first, followed by increases in CSF MCP-1, which immediately preceded or coincided with a rebound of CSF VL. CONCLUSION: The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other.

return to publications listing