Publication Abstract Display | Type: Published Manuscript | Title: Updated research nosology for HIV-associated neurocognitive disorders. | Authors: Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE | Year: 2007 | Publication: Neurology | Volume: 69 Issue: 18 Pages: 1789-1799 | Abstract:In 1991, the AIDS Task Force of the American Academy of Neurology published nomenclature
and research case definitions to guide the diagnosis of neurologic manifestations of HIV-1 infection.
Now, 16 years later, the National Institute of Mental Health and the National Institute of
Neurological Diseases and Stroke have charged a working group to critically review the adequacy
and utility of these definitional criteria and to identify aspects that require updating. This report
represents a majority view, and unanimity was not reached on all points. It reviews our collective
experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of
highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities;
and suggests inclusion of the term asymptomatic neurocognitive impairment to categorize
individuals with subclinical impairment. An algorithm is proposed to assist in standardized
diagnostic classification of HAND. |
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